Prenol lipids
Apexbio Technology LLC Menthol 1490-04-6 100mg
Menthol (CAS 1490-04-6) is a widely used small molecule modulator of the TRPM8 ion channel which is implicated in cold sensation By activating TRPM8 menthol induces a cooling response in sensory neurons It also inhibits neuronal calcium channel currents contributing to its analgesic and anti-irritant properties In animal studies menthol has been shown to reduce aversive responses to oral nicotine administration in mice Due to these pharmacological actions menthol serves as a reference standard in biomedical research focused on pain perception sensory modulation and mechanisms of addiction
Medchemexpress LLC Docetaxel | 114977-28-5 | 99.9% | C43H53NO14 | 1 G
Docetaxel is a microtubule depolymerization inhibitor with an IC50 of 0.2 μM. It attenuates the effects of bcl-2 and bcl-xL gene expression, arrests the cell cycle at G2/M, and leads to cell apoptosis. Docetaxel exhibits anti-cancer activity.
- Microtubule depolymerization inhibitor
- Attenuates bcl-2 and bcl-xL gene expression
- Arrests cell cycle at G2/M
- Leads to cell apoptosis
- Exhibits anti-cancer activity
Selleck Chemical LLC Alantolactone
Alantolactone a naturally occurring eudesmane-type sesquiterpene lactone (SL) could induce activin/SMAD3 signaling and disrupt Cripto-1/activin receptor type II A interaction
Cambridge Isotope Laboratories Vitamin B3 (nicotinic acid) (13C6 99%) 1 mg
Vitamin B3 (nicotinic acid) (13C6 99%) 1 mg
Medchemexpress LLC (rel)-β-Tocopherol | 148-03-8 | 99.9% | 416.69 | 10 MG
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol, a lipid-soluble form of vitamin E. It exhibits antioxidant activity and is utilized in various biological studies.
- Functions as a relative configuration of β-Tocopherol.
- Provides antioxidant activity.
- Slightly inhibits A7r5 and CHO cell proliferation.
- Inhibits PMA-induced adhesion of human erythroleukemia (HEL) cells.
- Inhibits the expression of integrins α4 and α5 on cell surface.
Medchemexpress LLC BIMAX2 acetate | 98.7% | 3561.98 | 5 MG
BIMAX2 acetate is a high-affinity nuclear localization signal (NLS) peptide that mimics the activity of the classical nuclear localization signal (cNLS). It competitively binds to importin α, inhibiting the binding of cNLS-cargo proteins to importin α. This peptide is useful for studying the role of RBBP4 in regulating nuclear import efficiency and cell senescence.
- Mimics classical nuclear localization signal (cNLS) activity.
- Competitively binds to importin α.
- Inhibits binding of cNLS-cargo proteins to importin α.
- Useful for studying the role of RBBP4 in regulating nuclear import efficiency and cell senescence.
Medchemexpress LLC (rel)-β-Tocopherol | 148-03-8 | 99.9% | 416.69 | 1 MG
(rel)-β-Tocopherol is a relative configuration of β-Tocopherol. β-Tocopherol is a lipid-soluble form of vitamin E that exhibits antioxidant activity. It is intended for research use only and not for human consumption.
- β-Tocopherol (50 μM, 48 hours) has been observed to slightly inhibit the proliferation of A7r5 cells (10% inhibition) and CHO cells (20% inhibition), while showing no inhibitory effect on HeLa cells.
- It also inhibits PMA-induced adhesion of human erythroleukemia (HEL) cells (11% inhibition) and the expression of integrins α4 and α5 on the cell surface when applied at 50 μM for 24 hours.
- Appearance: Solid-Liquid Mixture
- Color: Colorless to off-white
- In ethanol: 50 mg/mL (119.99 mM); requires sonication.
- In a solution of 10% Ethanol, 40% PEG300, 5% Tween-80, and 45% Saline: ≥ 1.25 mg/mL (3.00 mM) as a clear solution.
Cayman Chemical 23-hydroxy BetulInIc AcId 25mg
A triterpenoid with anticancer activity; inhibits proliferation of K562, B16, and HeLa cells (IC50s = 39.9, 78.5, and 80 µM, respectively), as well as HUVECs (IC50 = 94.8 µM); halts the cell cycle at the S phase and induces apoptosis in K562 cells
Cayman Chemical Paclitaxel Neurochemicals
A potent disruptor of microtubules used as a chemotherapeutic compound; inhibits growth of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas with IC50 values ranging from 2.5-7.5 nM; induces mitotic arrest and initiates apoptosis of cancer cells through multiple mechanisms
![Medchemexpress LLC 3-Quinolineethanol, 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αR,βS)-rel- | 654653-93-7 | 97.56% | 555.50 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000429420-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 3-Quinolineethanol, 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αR,βS)-rel- | 654653-93-7 | 97.56% | 555.50 | 25 MG
rel-Bedaquiline is a drug impurity.
- Target: Drug Intermediate
- Molecular formula: C32H31BrN2O2
- Molecular weight: 555.50